Ub: monomeric ubiquitin. (B–D) Levels of poly-ubiquitinated proteins in tissue homogenates from (B) the substantia nigra (SN), (C) the striatum (STR), (D) cortex (Ctx). SN present a significant age-dependent accumulation of poly-ubiquitinated proteins [F(3,11) = 8.703, p = 0.003]. *p
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