Molecular and histological evidence suggests that in these rodents, there is a natural resistance to insulin due to their lower metabolic activity and their reduced insulin receptor binding affinity

The Octodon degus, is a South American caviomorph rodent that develops spontaneous diabetes mellitus and has been found to have islet amyloidosis. The main protein of enriched and purified amyloid from Octodon degus pancreatic islets was identified as insulin.
Animals fed a diet of simple fruit sugars can readily develop diabetes mellitus along

With cataracts (Edwards 2009). The high susceptibility of this animal to develop diabetes shortly after streptozotocin injections, or secondary to minimal changes in its diet, makes it an attractive animal model for the study of the pathophysiology of diabetes mellitus.

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