It is the best-established model in biomedical research. For the sake of the study of human neuropathological processes, it combines the advantage of a comparable mammalian biology - including the complexity of the brain and diversity of its cell types and functions - with the growing availability of genetically modified strains plus extensive physiological, structural and behavioural tools. In addition, it is possible to rapidly achieve manipulations of gene expression in the CNS by methods that include the use of RNA interference (sRNAi) and over-expression, delivered through viral vectors.We hold several transgenic mouse lines for FSX, ASD and Asperger Syndrome and have the capacity to hold new lines (for more info contact us).
A small rodent with a body length of 25 cm and a weight of 170 to 300 grams.
Degus entered the research spotlight due to their unique relationship with sugar and diabetes, but are also studied for a wide variety of other reasons. Neuroscientists use degus for research into Alzheimer’s Disease (AD), they are the only mammals that naturally develop Alzheimer’s at 2.5-3 years of age. In elderly degus, neural markers have been discovered which are remarkably similar to those in humans with Alzheimer's, which is the first time this has been seen in a non-human mammal.
These are also animals with good eye-and-paw coordination and circadian rhythm: degus have the ability to show both diurnal and nocturnal rhythms if the environment permits, allowing a unique opportunity for study. Degus have also been found to spontaneously stack objects in order of decreasing size: it is the first time that this behaviour has been recorded in animals other than apes.Octodon degus are rodents that are becoming more widely used in the neuroscience field. Degus display several more complex behaviors than rats and mice, including complicated social behaviors, vocal communications, and tool usage, for these complex behaviors to be correlated with specific
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Seluanova et al. PNAS (2009) 106 (46):19357
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim et al Nature (2011) 479:223.
Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease. Edrey et al. Neurobiol Aging. (2013) : S0197-4580.
Blunted behavioral and c Fos responses to acidic fumes in the African naked mole-rat. LaVinka and Park. PLoS One. (2012)7(9):e45060.
Adult naked mole-rat brain retains the NMDA receptor subunit GluN2D associatedwithhypoxiatoleranceinneonatalmammals.Petersonetal. Neurosci Lett. (2012) 506(2):342-5.
A stereotaxic atlas of the brain of the naked mole-rat (Heterocephalus glaber). Xiao et al. Neuroscience. (2006) 141(3):1415-35.
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