octodon degus
human
what do they have in common
Degus are a natural model that age like humans.
The ageing process in the O. degus resembles that in humans at a molecular and at a behavioural level. Degus can help us in drug discovery increasing chances of success.
The Octodon degus is a natural model of ageing and Alzheimer’s disease (AD), thus, NOT all old animals will age the same or have AD. We should not treat natural models as trangenics and expect that a sample size of 3 animals will reveal much…as recently reported by Bourdenx (2017)...
We should not treat natural models as transgenics, would we use a simple size of 3 humans taken at random for a serious AD project?. Thus, although the usefulness of transgenic mice is undisputed, we hypothesized that additional relevant information on the physiopathology of Ageing and AD could be obtained from other natural non-transgenic models like the Octodon degus.
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naked mole rat
human
what do they have in common
The naked mole-rats (Heterocephalus glaber) NMR is a live long rodent.
The Naked Mole-Rat: A New Long-Living Model for Human Aging Research.
Tremendous variation in maximum life span among species overshadows modest increases in longevity resulting from experimental manipulation. Few aging studies focus on long-lived mammals like the Octodon degus and the Naked Mole Rat even though these species may expose mechanisms involved in resisting aging.
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