Plasmid or Adeno-associated virus-mediated gene transfer to the mouse CNS

Prenatal and Postnatal in vivo Assessment of Phenotypic Effects on a Pitt Hopkins Syndrome Mouse Model and Human Neurons

•  In utero electroporation to understand the developmental effect of gene insertion

•  Transcranial or tail vein injections

•  Human neurons (control group) 

•  Analysis of neuronal spine morphology

•  Behavioral assessment from postnatal to adult mice

•  Electrophisiology

In utero gene electroporation
Transcranial or tail gene delivery
Neuronal spine analysis
High throughput behavioural assays

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Office 7 35-37 Ludgate Hill
London, England


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