Plasmid or Adeno-associated virus-mediated gene transfer to the mouse CNS

Prenatal and Postnatal in vivo Assessment of Phenotypic Effects on a Pitt Hopkins Syndrome Mouse Model and Human Neurons

• In utero electroporation to understand the developmental effect of gene insertion
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• Transcranial or tail vein injections

• Human neurons (control group)
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• Analysis of neuronal spine morphology
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• Behavioral assessment from postnatal to adult mice
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• Electrophisiology

In utero gene electroporation

Transcranial or tail gene delivery

Neuronal spine analysis

High throughput behavioural assays

Electrophisiology

GeN Ltd
Office 7 35-37 Ludgate Hill
London, England
EC4M 7JN
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+442071938819

[email protected]

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