The Naked mole-rats (NMRs approximately 35 grams) are the longest-living (>28.3 years) rodents known. Shared characteristics with calorie-restricted, methionine-restricted, and dwarf mice models of extended longevity include reduced body temperature; reduced thyroid, and blood glucose concentrations; and low glycated hemoglobin; in addition to reduced incidence of cancer.
Young naked mole-rats surprisingly have high levels of accrued oxidative damage. With their similar longevity quotient to humans, these rodents may provide a novel opportunity to examine mechanisms modulating aging. Like with the Octodon degus, a good way to differentiate healthy and unhealthy animals should be used with the NMR and as well as a big sample.
Google is studying naked mole rats to help slow human ageing. The Naked mole rats have developed biological defences against cancer and feel little pain.
Bill Maris, the former head of Google Ventures who came up with the idea for Calico, believes it should be possible for people to live “for 500 years”. Learning about the African naked mole rat is key to this plan.
Mechanisms of resistance to DNA damage in the naked mole-rat, a long-lived and cancer-resistant mammal.
We use the Heterocephalus to analyzed for markers of cellular senescence and apoptosis, in order to identify novel compounds to cherry. Our lab is already employing state-of-the-art next-generation sequencing technologies to study Heterocephalus and analyze its genome and transcriptome to find novel pharmacological targets.
As a Biopharmaceutical company, we use the Heterocephalus to analyzed for markers of Cellular senescence and apoptosis, in order to identify novel compounds for our pipe line.
We employ state-of-the-art next-generation sequencing technologies to study the
Heterocephalus and analyze its genome and transcriptome to find novel pharmacological agents.
Moreover, we perform bioinformatics analyses on the Heterocephalus genome
and transcriptome to identify genes and mechanisms to serve as
new foci to find new ageing drugs for human applications.
The naked mole rat shows an over expression of DNA repair genes when compared with humans.